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What is the organic compound of bone matrix?
Collagen, a ropelike, fibrous protein, is the major organic component of bone. Like rope, collagen has significant mechanical strength under tension. Therefore, collagen provides tensile strength to the bones.
What is bone matrix made of?
Bone matrix Osteoid is comprised of type I collagen (~94%) and non-collagenous proteins. The hardness and rigidity of bone is due to the presence of mineral salt in the osteoid matrix, which is a crystalline complex of calcium and phosphate (hydroxyapatite).
What are the major minerals found in the bone matrix?
The major minerals found in bone are calcium and phosphorus in the form of an insoluble salt called hydroxyapatite [chemical formula: (Ca)10(PO4)6(OH)2]. Hydroxyapatite crystals lie adjacent and bound to the organic protein matrix.
What percentage of bone is organic?
approximately 30%
COMPOSITION OF BONE The organic component of bone comprises more than 30 proteins with type I collagen being the most abundant (>90%) [1,2,12]. By weight, the inorganic constituent accounts for about 60% of the tissue while the organic component makes up approximately 30%.
Why are bones alive?
In fact, bones, like all other tissues in your body are alive. Because bones are the main support structure for us, they are made of a hard material that is mainly calcium. Throughout this hard substance, are blood vessels and nerves. Anything that is alive in the body needs these things to nourish it.
Where are minerals stored in the bone?
matrix
Bone stores minerals in its matrix. It stores 99% of calcium and 85% of phosphorus of our body.
What makes up the organic matrix in the bone?
Organic Matrix known as osteoid; consists of collagenous fibers(helps bone resist twisting and pulling/stretching forces), proteoglycans, glycosaminoglycans, glycoproteins, and bone-specific proteins
What makes up the composition of the bone?
Bone/Osteo components Bone composition: organic proteins, collagen, and inorganic minerals. Approximately 30% organic and 70% inorganic Organic bone is either cortical (lamellar) bone or trabecular/cancellous (non-lamellar) bone. Cortical bone, sometimes referred to as “compact bone,” is found on the hard surface of bone.
What is the role of cell-bone matrix interaction?
CELL-BONE MATRIX INTERACTION IN PHYSIOLOGIC PROCESSES. The cell-bone interaction plays a pivotal role in physiologic bone remodeling which is a lifelong process of bone renewal in which old bone is resorbed by osteoclasts and then replaced by new bone formed by osteoblasts [1,23].
Where is Osteonectin found in the bone matrix?
Within skeletal tissues, osteonectin is expressed in osteoprogenitor cells, osteoblasts, young (but not old) osteocytes, hypertrophic chondrocytes (HCCs) of mineralising cartilage, fracture callus and ectopic ossification, the latter as seen in fibrodysplasia ossificans progressiva (discussed in Chapter 11).