What are the organic components of the extracellular matrix?

What are the organic components of the extracellular matrix?

The organic component of the bone matrix includes the collagen and ground substance whereas the inorganic component is the inorganic bone salts, mainly the hydroxyapatite.

What makes up the organic and inorganic portions of the extracellular matrix?

As described above, by volume, bone consists of 40% inorganic component (hydroxyapatite), 25% water and 35% organic component (proteins) [1,2,12]. 90% of the organic component are collagen type I and the remaining 10% noncollagenous proteins.

What does the organic portion of the extracellular matrix space provide?

Within the matrix, the mineral crystals resist compression but are very brittle. The organic components, such as the collagen fibers and the cells, help give the bone some flexibility.

What does organic matrix contain?

Organic Components: – The organic component of the bone matrix is called osteoid. – It contains proteoglycans, glycoproteins and collagen fibers. They provide bone with great flexibility and tensile strength (resistance to being stretch or torn apart).

What is bone matrix made up of?

Bone matrix (also known as osteoid) consists of about 33% organic matter (mostly Type I collagen) and 67% inorganic matter (calcium phosphate, mostly hydroxyapatite crystals). The osteoblasts occur as simple, epithelial-like layer at the developing bone surface.

What mineral is rich in bone matrix?

The bone matrix is rich in calcium and phosphorus. Bone Matrix consists of substances such as inorganic bone salts and collagen fibers. Bone matrix is a protein matrix that contains minerals like calcium and phosphorus which get deposited and form bones.

What is an example of extracellular matrix?

In animal tissues, the main components of the extracellular matrix are the fibrous elements (e.g. collagen, elastin, reticulin), link proteins (e.g. fibronectin, laminin), and space filling molecules (e.g. glycosaminoglycans). In plant tissues, the extracellular matrix includes cell wall components such as cellulose.

What does an extracellular matrix do?

The extracellular matrix determines the structure and function of tissue through a complex network of macromolecules. The composition of the extracellular matrix differs between tissue types. Though its main function is to provide an essential scaffold for cells, the extracellular matrix also regulates processes by controlling cell communication.

What tissue has the presence of an extracellular matrix?

Currently, these scaffolds are produced from extracellular matrix (ECM) of a wide variety of tissues, including the small intestine submucosa (SIS) , urinary bladder matrix (UBM) , central nervous system , esophagus , liver , skeletal muscle , lung , umbilical cord , adipose tissue , dermis , colon , cartilage , and bone , among others.

What are the fibers of the extracellular matrix made of?

The structure of the extracellular matrix differs in composition between tissue types but is essentially made up of collagen fibers, proteoglycans and multiadhesive matrix proteins that are secreted by cells. The functions of the extracellular matrix include:

What makes up the extracellular matrix of connective tissue?

Connective tissue is made up of cells and extracellular matrix. The extracellular matrix is made up of fibres in a protein and polysaccharide matrix, secreted and organised by cells in the extracellular matrix. Variations in the composition of the extracellular matrix, determines the properties of the connective tissue.