How do I take mifepristone and misoprostol at the same time?

How do I take mifepristone and misoprostol at the same time?

Group 1: mifepristone 200 mg orally followed within 15 minutes by misoprostol 800 mcg vaginally. Group 2: mifepristone 200 mg orally followed by misoprostol 800 mcg vaginally 23–25 hours later. Follow-up 1: scheduled visit 7 (±1) days after mifepristone. Follow-up 2: scheduled visit 14 (±2) days after mifepristone.

Do I have to wait 24 hours to take misoprostol?

The FDA label recommends misoprostol 800 mcg buccally from 24-48 hours after mifepristone. An alternate evidence-based route is vaginal misoprostol administration, allowing a window of 6-72 hours after mifepristone.

What should I do after taking mifepristone and misoprostol?

Go to an emergency room if you still have any of the following symptoms more than 24 hours after taking misoprostol: fever, severe stomach pain, heavy or prolonged vaginal bleeding, nausea, vomiting, diarrhea, or feeling like you might pass out. Be sure to tell your caregivers when you last took misoprostol.

How are misoprostol tablets taken?

Take the 4 misoprostol pills. Put 2 pills on one side of your mouth, and the other 2 on the other side of your mouth. Wait 3 minutes for the pill to dissolve. After 30 minutes, swallow what is left of the pills.

What is the time gap between mifepristone and misoprostol?

The recommended time interval between mifepristone and the first dose of misoprostol has been 36–48 h, as the maximal effect of mifepristone is reached at that point (Gemzell-Danielsson and Lalitkumar, 2008).

How long does mifepristone stay in your body?

Following a distribution phase, elimination of mifepristone is slow at first (50% eliminated between 12 and 72 hours) and then becomes more rapid with a terminal elimination half-life of 18 hours.

How many hours after taking mifepristone should I take misoprostol?

You will need to take misoprostol 36–48 hours after taking mifepristone. The usual dose is 800 micrograms (4 tablets) of misoprostol. Misoprostol must be taken bucally. This means you must keep each tablet between the cheek and gum for 30 minutes before swallowing any remaining fragments with water.

What are signs of an incomplete abortion?

Signs of an Incomplete Abortion

• Bleeding more than expected.
• Bleeding that doesn’t get lighter after the first few days.
• Bleeding that lasts more than three weeks.
• Very severe pain or cramps.
• Pain that lasts longer than a few days.
• Discomfort when anything presses on your belly.

Who should not take mifepristone?

Before using this medicine, consult your doctor if you have any of the following: undiagnosed abdominal growth (adnexal mass), certain adrenal gland problem (chronic adrenal failure), bleeding problem (e.g., coagulopathy), certain blood disorder (inherited porphyrias), IUD (intrauterine birth control device) in place.

Can mifepristone be taken orally with water?

Take mifepristone by mouth as directed by your health care professional, usually as a single dose. Swallow the mifepristone with a glass of water. After taking mifepristone, wait 24 to 48 hours, then take the misoprostol (as a single dose).

How long does mifepristone stay in your system?

What are the dangers of incomplete abortion?

[4] There are several other complications that can arise after the management of incomplete abortion including death, uterine rupture, uterine perforation, subsequent hysterectomy, multisystem organ failure, pelvic infection, cervical damage, vomiting, diarrhea, infertility, and/or psychological effects.

What is the proper way to take misoprostol?

Misoprostol is a prescription medication that is frequently given to patients taking non-steroidal anti-inflammatory drugs ( NSAIDs ) as a way to prevent gastric ulcers. It will typically be taken for as long as a patient’s NSAID treatment lasts. Take Misoprostol with food or milk, 4 times a day as recommended by your doctor.

How many tablets of misoprostol should I take?

Misoprostol Dosage for Women Under 9 Weeks Pregnant: You will need a minimum of 8 pills of Misoprostol. Each pill should be 200 mcg. [3]

How should I take the misoprostol pills?

How to take Mifepristone and Misoprostol for a safe abortion Swallow the Mifepristone pill with water. If you throw up in the first 30 minutes after swallowing Mifepristone, it is likely that the pill will not work. Take 800 mg of Ibuprofen 1 hour before using Misoprostol. This step is not required, but it is highly recommended. Place 4 Misoprostol pills under your tongue (sublingual) for 30 minutes.

How should misoprostol be taken?

When misoprostol is prescribed for the treatment or prevention of ulcers, it is prescribed in tablet form. The prescribed dose is usually taken four times a day. Misoprostol should be taken with food and it is recommended to be taken after a meal and before at bedtime with a snack.