What is abciximab infusion used for?

What is abciximab infusion used for?

Abciximab is widely used in interventional cardiology for the treatment of unstable angina and as an adjunct therapy following percutaneous coronary intervention.

Is abciximab still available?

The US Food and Drug Administration has listed abciximab 2 mg/mL vials as “currently in shortage,” though other regulators were notifying practitioners much earlier.

How is abciximab produced?

Abciximab is produced by continuous perfusion in mammalian cell culture. The Fc fragment is cleaved with papain, and the Fab fragment is purified from the cell culture supernatant by column chromatography.

What is the class of abciximab?

Abciximab is a monoclonal anti-glycoprotein IIb/IIIa receptor antibody used to prevent thrombosis during percutaneous coronary intervention. Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3.

Is abciximab reversible?

Abciximab is a noncompetitive irreversible inhibitor of GPIIb/IIIa. It is the humanized chimeric Fab fragment of the monoclonal mouse antibody 7E3. Eptifibatide and tirofiban are low-molecular-weight competitive and reversible GPIIb/IIIa antagonists that act specifically on the αIIb-subunit of GPIIb/IIIa.

When can I stop abciximab?

With the exception of recent drug-eluting stent implantation, clopidogrel bisulfate use should be stopped at least 5 days prior to most elective surgery. Use of glycoprotein IIb/IIIa inhibitors must be discontinued preoperatively for more than 12 hours to allow normal hemostasis.

Why was abciximab discontinued?

Janssen had Reopro on shortage due to a production interruption at their third party manufacturing site. Janssen is not pursuing new lots of Reopro. There are no other suppliers of abciximab.

What is bivalirudin made from?

Bivalirudin (Bivalitroban), sold under the brand names Angiomax and Angiox and manufactured by The Medicines Company, is a direct thrombin inhibitor (DTI). Chemically, it is a synthetic congener of the naturally occurring drug hirudin, found in the saliva of the medicinal leech Hirudo medicinalis.

When do you use abciximab?

USES: Abciximab is a type of “blood thinner” used to prevent blood clots during certain procedures used to open up the blood vessels in the heart (e.g., balloon angioplasty, coronary stent placement, percutaneous coronary intervention-PCI). It is usually used with heparin and aspirin.

How is abciximab cleared?

Unbound abciximab is rapidly cleared from plasma by proteolytic degradation, resulting in a very short plasma half-life (several minutes), whereas the biological half-life ranges from 8 to 24 hours. As such, some GPIIb/IIIa receptors may still be occupied by drug up to 2 weeks after discontinuation of drug infusion.

How do you reverse abciximab?

Currently, there is no available reversal agent. Therefore, platelet transfusion is recommended for reversing the effect of abciximab. Eptifibatide (Integrilin) is approved for use in patients with acute coronary syndrome, including patients scheduled for PCI.

What kind of surgery is abciximab used for?

Abciximab or Abcixifiban (previously known as c7E3 Fab ), a glycoprotein IIb/IIIa receptor antagonist manufactured by Janssen Biologics BV and distributed by Eli Lilly under the trade name ReoPro, is a platelet aggregation inhibitor mainly used during and after coronary artery procedures like angioplasty to prevent…

How long does abciximab stay in the blood?

It is a glycoprotein IIb/IIIa inhibitor. While abciximab has a short plasma half-life, due to its strong affinity for its receptor on the platelets, it may occupy some receptors for weeks. In practice, platelet aggregation gradually returns to normal about 96 to 120 hours after discontinuation of the drug.

What kind of antibody is abciximab for platelets?

Abciximab, ReoPro®, is the Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation.

How does abciximab bind to the GP receptor?

Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation . Abciximab also binds to the vitronectin (α v β 3) receptor found on platelets and vessel wall endothelial and smooth muscle cells. The chimeric 7E3 antibody is produced by continuous perfusion in mammalian cell culture.